Conférence : Role of phosphoinositides and ion channels in endocytosis and phagocytosis

Tuesday September 10, 2019 | Activités

Organisée en collaboration avec l’axe Inflammation-douleur

Invité : Sergio Grinstein, Ph. D.

Professor, Department of Biochemistry, University of Toronto
Senior Scientist, Centre for Research and Learning, Hospital for Sick Children


10 septembre 2019, 12 h


local 2999

Résumé | Little is known about how endomembrane size and shape are regulated. To investigate the underlying mechanisms, scientists like Pr Grinstein used high-resolution video imaging to analyze the formation and fate of phagosomes and macropinosomes in macrophages. Specific fluorescent probes were used to track unique proteins and phosphoinositides suspected to play key roles in these processes.

The seminar will discuss the formation and dynamics of podosome-like structures during phagocytosis and their regulation by PtdIns(4,5)P2. In the second part, the seminar will describe the role of TPC channels and their regulation by PtdIns(3,5)P2 in macropinosome remodeling and resolution.


Un buffet froid sera servi sur place.

Conférence disponible en visioconférence.

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