The axis brings together researchers with diverse expertise such as biochemistry, cellular and molecular biology, intracellular signaling, RNomics, proteomics, functional genomics, genomic instability, bioinformatics, oncology and gastroenterology, physics, nuclear medicine, and radiobiology.
Basic-science researchers and clinicians work together to:
- Understand the mechanisms underlying cancer biology
- Integrate fundamental knowledge into clinical practice
- Develop new diagnostic strategies and treatment approaches
Some of our outreaching strengths:
- Establishment of a tumor biobank and development of complementary mouse models integrating the main characteristics of colorectal carcinogenesis
- Improving the effectiveness of radiation-therapy treatments through the development of radiosensitivity agents
- Use of RNomics in developing more individualized and more sensitive diagnostic approaches
New technologies are also being explored to offer a more effective and less harmful alternative to conventional radiation therapy.
Although the research projects cover a significant number of disciplines, everyone involved is committed to improving the understanding, detection, diagnosis, and treatment of many gynecological, gastrointestinal, and brain cancers.
Axis Director | Benoît Chabot, Ph. D., FCAHS
Axis Coordinator | Karine Tremblay
- Integrative cancer biology involving functional genomics and RNA biology
- Biology of the gastrointestinal epithelium related to the appearance and evolution of colorectal cancer
- DNA integrity related to chemotherapy agents and ionizing radiation
- Development and clinical transfer of new approaches combining chemotherapy and radiation therapy
- Effect of radiation on tumor malignant progression