Martin Bisaillon, Ph. D.
Elucidation of the molecular mechanisms of proteins involved in the synthesis and maturation of messenger RNAs
The long-term objective of Doctor Bisaillon's research program is to understand the molecular mechanisms which dictate the interactions between enzymes and their ligands. He is particularly interested by the proteins from infectious agents which interact with RNA, metal ions, and/or nucleotides since important gaps still exist in our comprehension of the mechanisms which govern the interactions between these macromolecules. His research program concentrates on various infectious agents such as West Nile virus, Hepatitis C virus, vaccinia virus, influenza virus, and the yeast Candida albicans.
His laboratory uses proteins involved in the synthesis/maturation of messenger RNAs (mRNAs) of these organisms to understand how proteins interact with various ligands. The majority of mRNAs from viral/fungic origins undergo many co-transcriptional modifications before being translated effectively into proteins. These modifications include the addition of a cap structure at the 5 ' ends of mRNAs, edition, splicing, and polyadenylation at the 3' ends of mRNAs. The laboratory of Doctor Bisaillon uses a multidisciplinary approach in order to better understand the enzymatic reactions, the structural modifications, and the thermodynamics of various reactions involved in the synthesis/maturation of mRNAs. A better knowledge of the biochemical properties of these proteins should possibly lead to the development of antiviral/antifungal strategies. The inhibition of the enzymatic activities that are essential for viruses/yeast has obvious implications for the development of new therapies against infectious diseases.
- New Investigator Research Scholar from CIHR, Junior II and Senior Research Scholar from FRQ-S
- Operating grants as principal investigator from CIHR and NSERC for a total of $ 2 M over the last ten years
- Discovery of many inhibitors of enzymatic reactions
Know-How & Opportunities for Collaboration
- Expression and purification of proteins
- Fluorescence spectroscopy
- Thermodynamics of intermolecular interactions
- Molecular modeling of proteins-ligand complexes