Brendan Bell, Ph. D.
Cancer : Biology, Prognosis, and Diagnosis Axis
Centre de recherche du CHUS
Department of Microbiology and Infectious Diseases
Faculty of Medicine and Health Sciences
Université de Sherbrooke
Phone | 819-346-1110 ext. 75327
E-Mail | Brendan.Bell@usherbrooke.ca
Identifying mechanisms underlying the abnormal expression of genes in cancerous or HIV-infected cells
Today, cancer is the leading cause of premature death in Canada, while AIDS kills the largest number of people worldwide. In order for effective therapies to fight these fatal diseases to be found, it is essential to acquire a better understanding of a number of molecular mechanisms operating in affected cells.
Doctor Brendan Bell’s research aims to identify the disruptions in the expression of genes in cancerous cells and in cells infected by HIV while the virus is still in a latent state.
Doctor Bell’s starting point is the finding that a number of cancers are associated with alteration of the process that normally determines the programmed death of diseased cells.
Doctor Bell’s overall goal is to understand and determine how cell death signals express themselves at the molecular level.
With respect to AIDS, Doctor Bell’s work focuses on the latency mechanisms of the HIV virus, and more particularly, the HIV-1 promoter and virus transcription.
Existing therapies are unable to destroy HIV in infected cells when the virus in still in a latent state.
Doctor Bell’s work could lead to the development of new gene therapies for cancer and AIDS over the next few years.
- Canada Research Chair in Mechanisms of gene expression (2004-2009)
Know-How & Opportunities for Collaboration
- Molecular oncology
- Cell biology