François Bachand, Ph. D.
Cancer : Biology, Prognosis, and Diagnosis Axis
Centre de recherche du CHUS
Department of Biochemistry
Faculty of Medicine and Health Sciences
Université de Sherbrooke
Phone | 819 346-1110 ext. 72733
E-Mail | F.Bachand@USherbrooke.ca
Mechanisms of Post-transcriptional Gene Regulation
Gene expression is the process by which the genomic information is used for the synthesis of messenger RNA (mRNA), required for protein synthesis. In most cancers, however, the expression of several genes is abnormal.
To better understand how gene expression is controlled in normal cells and cancer, the investigator François Bachand’s laboratory focuses on two distinct aspects of post-transcriptional gene regulation. On the one hand, he examines the role of various cytoplasmic and nuclear proteins that bind the poly (A) tail of RNA in the control of gene expression. On the other hand, his laboratory studies how post-translational modifications, especially arginine methylation, modulate the function of various RNA-binding proteins. His research group uses the most advanced methods in molecular biology, genomics, and proteomics to address these questions. His research is expected to lead to the discovery of new targets for treatment of several diseases.
Doctor Bachand obtained a B.Sc. in Microbiology and Immunology (McGill, 1996) and a M.Sc. from Université de Montréal (1998) and a Ph. D. in anatomy and cell biology (McGill, 2002). He then completed a postdoctoral fellowship at the Dana Farber Cancer Institute, affiliated with Harvard University (Boston).
- Canada Research Chair - $500 000 per year over 5 years
- $537 340 over five years from the Canadian Institutes of Health Research (CIHR) - Molecular control of ribosome biogenesis
- $668 285 over five years from the Canadian Institutes of Health Research (CIHR) – Characterization of the molecular basis of oculopharyngeal muscular dystrophy
- Finalist for the Maud Menten Award from the CIHR Institute of Genetics
- Recipient of a Career Development Award from the International organization, Human Frontier Science Program
Know-How & Opportunities for Collaboration
- Molecular Genetics
- Gene Expression Studies
- Genomic and Proteomic Approaches