Daniel Houde, Ph. D.

Daniel HoudeInvestigator
Cancer: Biology, Prognosis, and Diagnosis Axis
Centre de recherche du CHUS

Full Professor
Department of Nuclear Medicine and Radiobiology
Faculty of Medicine and Health Sciences
Université de Sherbrooke

Contact Information
Phone | 819 346-1110 ext. 14502

E-Mail | Daniel.Houde@USherbrooke.ca


Research relevance

Biomedical applications of ultra-short laser technology: Studies of transitory chemical physic processes of medical interest

Cancer is a leading cause of death in western societies. Current therapies against cancer are heavy and affect the quality of life of patients as well as having an impact on healthy tissues. In the arsenal of the clinician, in addition to cancer photodynamic therapy (PDT), radiotherapy occupies a very important place. The last major innovation occurred in 1946 with the proposal to use proton radiotherapy. However, the ideal dose deposition, that ensures full protection of healthy tissue, cannot be produced by any of these methods. Currently no protocol based on the action of ionizing radiation has produced this ideal dose deposition.

Physicist by training and specialist in the interaction of ultra-short laser and matter, the investigator Daniel Houde develops new approaches for the treatment of cancer based on femtosecond lasers. He has developed a patented new method that produces this ideal dose deposition in the tumor and constitutes an alternative to cancer treatment by radiotherapy. He also developed a two-photon PDT approach enabling the patient to overcome the inherent light sensitivity of this technique.


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Representative Achievements

  • Invention of laser radiotherapy (Meesat et. al, Proc. Ntl. Acad. Sci. USA 109, E2508-E2513, (2012), D. Houde et. al. , U.S. Provisional Patent Application No 61/313.553, Patent Cooperation (PCT), WO 2011/109907 A1, U.S.A.Patent No.13/580,038 (2012), Canadian Patent PCT/CA2011/000273 (2012), Korean patent 10-2012-7026796.)
  • Member of the Regroupement Québécois sur les Matériaux de Pointes (RQMP)
  • Founding member of the Advanced Laser Light Source du Canada (ALLS)
  • Member of i-MOVI - Interactive MOlecular MOdelling and Visualization Infrastructure


Know-How & Opportunities for Collaboration

  • Expert in ultrafast spectroscopy on chemical-physics process on organic molecules
  • Co-holder of several patents on laser technology in medicine
  • Specialist of terahertz spectroscopy applied to organic molecules


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