Ghassan Bkaily, Ph. D.

Ghassan BkailyInvestigator
Diabetes, Obesity, and Cardiovascular Complications Axis
Centre de recherche du CHUS

Full Professor
Department of Anatomy and cell biology
Faculty of Medicine and Health Sciences
Université de Sherbrooke

Contact Information
Phone | 819 346-1110 ext. 15303

E-Mail | Ghassan.Bkaily@USherbrooke.ca

   

Research Relevance

Physiopathology and Pharmacotherapy of the Cardiovascular System

The research program of Doctor Bkaily’s group is to study the physiopathology and the pharmacology of the cardiovascular system and the role of the G-protein-coupled receptors, the tysosine kinase receptors in  the regulation of excitation-contraction coupling, excitation-secretion coupling and excitation-gene expression coupling. The research program includes:1-physiopathological role of released factors from the immune and endothelial systems on the cardiovascular system during fetal development and aging; 2- physiological and pathological role of the physical interaction between cardiovascular systems - endothelial - monocytic - lymphocytic; 3-role of nuclear membranes’ receptors  and inonic transportors in the development of cardiovascualr diseases; 4-physiopathological role of nuclear structures and free radicals; 5- molecular pharmacology of nuclear receptors; and 6-development of a new generation of drugs targeting nuclear membrane receptors.

 

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Representative Achievements

Major grants

  • CIHR, FQRNT team grant, NSERC and Heart and Stroke Foundation of Canada

Publications

  • Ahmarani et al. 2013. Whole-cell and nuclear NADPH oxidases levels and distribution in human endocardial endothelial, vascular smooth muscle, and vascular endothelial cells. Can J Physiol Pharmacol. 91(1):71-9
  • Bkaily et al. 2011. Nuclear membrane receptors for ET-1 in cardiovascular function. Am J Physiol Regul Integr Comp Physiol. 300(2):R251-63
  • Avedanian et al. 2011. Presence of tubular and reticular structures in the nucleus of human vascular smooth muscle cells. .J Mol Cell Cardiol. 50(1):175-86
  • Bkaily et al. 2012. Receptors and ionic transporters in nuclear membranes: new targets for therapeutical pharmacological interventions. Can J Physiol Pharmacol. 90(8):953-65
  • Chahine et al. 2005. NHE-1-dependent intracellular sodium overload in hypertrophic hereditary cardiomyopathy: prevention by NHE-1 inhibitor. J Mol Cell Cardiol. 38(4):571-82

   

Know-How & Opportunities for Collaboration

  • Electrophysiology and biophysics
  • Cardiovascular pharmacology
  • Membrane transporters
  • Real 3-D confocal microscopy
  • Cellular and molecular physiology
  • Nuclear function
  • Drug development

    

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