Jean-Patrice Baillargeon, M. D., M. Sc.
Diabetes, Obesity, and Cardiovascular Complications Axis
Centre de recherche du CHUS
Centre hospitalier universitaire de Sherbrooke
Department of Medicine and Physiology/Biophysics
Faculty of Medicine and Health Sciences
Université de Sherbrooke
Phone | 819 346-1110 ext. 14853
Fax | 819 564-5292
E-Mail | Jean.Patrice.Baillargeon@USherbrooke.ca
Reducing the Impact of Obesity on Metabolic and Endocrine Health in Women : exploring the role of fatty acids in the development of polycystic ovary syndrome, and lifestyle management of obesity in primary care.
Polycystic ovary syndrome (PCOS) is a common condition affecting 6-10% of women of childbearing age. It is the most frequent endocrine disorder among young women in Canada. PCOS is defined by hyperandrogenism, chronic anovulation and/or polycystic ovaries. Accordingly, affected women usually seek medical attention for esthetical complains (hair growth, acnea) or infertility. Despite all the effort made in finding the causal factor of this pathology, many questions still remain unanswered regarding the mechanisms by which insulin resistance or insulin produces hyperandrogenemia. Dr. Jean-Patrice Baillargeon’s research program aims to elucidate the role of non-esterified fatty acid (NEFA) into the pathogenesis of PCOS. Furthermore, lifestyle modification is essential to reduce PCOS lipotoxicity and the burden of obesity in Canada. Dr. Baillargeon also seeks to assess the best approaches to support primary care for obesity management. The ultimate goal of his research is thus to reduce the impact of obesity, mainly on women’s health, and facilitate rapid knowledge transfer to clinical application through a translational approach.
Briefly, his research program is composed of 2 principal aims; 1) Determine the impacts of NEFAs on the induction of androgenic hypersecretion and associated mechanisms. This aim is tested in vivo in women with or at risk for PCOS, and in vitro in bovine, canine or human ovarian and/or adrenal gland cell cultures. This part of the project is innovative as clinical aspects are in continuity with fundamental works in order to maintain a bench-to-beside relationship. 2) Evaluate the impacts of management of obesity, using lifestyle strategies, integrated to primary care practices and the fertility clinic.
After obtaining is medical doctorate and is speciality in endocrinology, Dr. Baillargeon acquired specialized expertise in reproductive endocrinology and biostatistics over a three years fellow and master degree in the U.S. at the Virginia Commonwealth University.
- Canadian Institutes of Health Research (CIHR) – $ 345,000 for 3 years
- Additional grants from the CIHR, Quebec ministry of health and social services, Foundation of Stars. Diabète Québec, Université de Sherbrooke, totalling over $ 70,000 / year
- Dr. Baillargeon has published over 75 peer-reviewed articles and book chapters
- Dr. Baillargeon supervises/has supervised 11 graduate students and postdoctoral fellows
Know-How & Opportunities for Collaboration
- Internationally renowned expert in obesity and mainly PCOS
- Well-recognized expertise for in vivo metabolic assessment in humans
- Demonstrated expertise in clinical research methodology and applied biostatistics