Abdelaziz Amrani, Ph. D.

Representative Achievements
Know-How & Opportunities for Collaboration
Scientific publications [PubMed]

Abdelaziz AmraniInvestigator
Inflammation-Pain Axis
Centre de recherche du CHUS

Full Professor
Department of Pediatrics | Immunology Division
Faculty of Medicine and Health Sciences
Université de Sherbrooke

Contact Information
Phone | 819 346-1110 ext. 14854

E-Mail | Abdelaziz.Amrani@USherbrooke.ca


Research Relevance

Cellular and Molecular Communication between Innate and Adaptive Immune Systems

Doctor Amrani's research program aims to understand the cellular and molecular mechanisms that control differentiation and function of dendritic cells, a central cell type in innate and adaptive immunity.  More specifically, his team investigates the role of dendritic cells in autoimmunity from two complementary angles: the mechanisms involved in controlling dendritic cells phenotype and function and the molecular interaction that use dendritic cells to regulate T cell responses. They are particularly interested in transcription factor-associated signaling pathways that control tolerogenic signature of dendritic cells in autoimmune diseases. They also investigate extracellular mechanisms by which dendritic cells mediate control of T cell differentiation (Th1/Th2/Treg and Th17) in autoimmunity. His laboratory uses a combination of approaches including genetically modified mice, cellular immunology and biochemistry, as well as models of autoimmune diseases such as diabetes, colitis and arthritis.


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Representative Achievements

  • CIHR operating grant (2013-2018) on the role of dendritic cells in protection against diabetes
  • CIHR Institute of Infection and Immunity grant (2013-2014)
  • Publications
  • Diabetes, 2008 and 2013; Cell. Immunol, 2010; Clin. Dev. Immunol., 2011


Know-How & Opportunities for Collaboration

  • Analysis and identification of immune cells by flow cytometry
  • Study of signaling pathways triggering dendritic cells function
  • Development and use of animal models of knockout and transgenic mice to study autoimmune inflammatory diseases


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