Frédéric Balg, M.D.

Frédéric BalgInvestigator
Inflammation-Pain Axis
Centre de recherche du CHUS

Centre hospitalier universitaire de Sherbrooke

Associate Professor
Department of Surgery | Orthopaedic Surgery Division
Faculty of Medicine and Health Sciences
Université de Sherbrooke

Contact Information
Phone | 819 346-1110 ext. 14233

E-Mail |


Research Relevance

Musculoskeletal problems are one of the most prevalent and important health issues in society, and the understanding of the clinical evolution of these pathologies is imperative. The comprehension of musculoskeletal tissue repair mechanisms is essential in the prevention of these lesions and in the evolution of improved treatment, in addition to the management of acute and chronic pain associated with these pathologies.

Investigator Frédéric Balg, physician-researcher, is an orthopaedic surgeon specialised in shoulder pathologies and sports medicine, as well as in the Ilizarov technique, used in limb lengthening, bone regeneration and correction of bone deformities. His clinical interests naturally focus on the analysis of the prognostic factors of shoulder pathologies and the improvement of their clinical evolution through surgical treatment, physical therapy, pain management and functional outcomes.

Dr. Balg actively collaborates with Investigator Guillaume Grenier and his laboratory on the comprehension of cellular mechanisms that are responsible for musculoskeletal pathologies. Recent collaborations have focussed on the creation of a mouse model of bone healing to determine the different factors contributing to bone formation. Several models of muscle degeneration are also used in the investigation of tendon and muscle pathologies due to under- or overuse. Studies on muscular stem cell populations have also led to interesting avenues in novel treatments for muscular, tendon and bone lesions.


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Representative Achievements

  • Creation of a predictive score for recurrent instability post-surgical shoulder stablisation (Balg F, Boileau P. The Instability Severity Index Score (ISIS Score): A Simple Preoperative Score to Select Patients for Arthroscopic or Open Shoulder Stabilization. J Bone Joint Surg Br 2007 ; 89B : 1470-1477)
  • BIomechanical evaluation of the shoulder reverse prosthesis and clinical results (Boileau P, Watkinson DJ, Hatzidakis AM, Balg F. Grammont Reverse Prosthesis : Design, Rationale, and Biomechanics. J Shoulder Elbow Surg 2005; 14 : 147S-161S)
  • CIHR – Heterotopic ossification following musculoskeletal trauma : Alteration of the stromal cell microenvironment and induction of osteogenic differentiation (2011-2016)
  • Centre de neurosciences de Sherbrooke/FRQ-S – Comprehension of the interaction between pain and the musculoskeletal system: A novel study combining transcranien magnetic stimulation and electroencephalography (2012-2014)
  • Réseau de ThérapieCellulaire – Development of a bioactive matrix for the treatment of fracture non-unions.


Know-How & Opportunities for Collaboration

  • Pre-operative, surgical and physical therapy clinical trials and prospective studies on musculoskeletal pathologies, namely shoulder pathologies (instability, tendinopathy, rotator cuff tear, arthopathy)
  • Perioperative pain management
  • Biomechanical evaluation on dry lab and cadaver models
  • Animal models of the evaluation of bone healing and musculoskeletal degeneration/regeneration
  • Isolation, purification and culture of skeletal muscle stem cells


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