Serge Marchand, Ph. D.
Neurophysiological mechanisms of the development, persistency and response to treatment in pain
The investigator Serge Marchand’s research program focuses on the characterization of different neurophysiological mechanisms involved in chronic pain (low back pain, fibromyalgia, neuropathic pain, irritable bowel syndrome, etc.). His team studies the interactions between different aspects of pain (pain intensity, unpleasantness) and scores of DNIC responses, concentrations of sex hormones (estrogen, progesterone, testosterone), age, autonomic responses, electrophysiological activity of the spine (nociceptive reflex [RIII]), and cortex (somatosensory evoked potentials [SEP]), brain imaging (fMRI and MR brain spectroscopy) and some phenotypes of neurotransmitters and their receptors.
Using these different approaches of investigation, the goal of Doctor Marchand’s research program is to characterize the specific factors involved in subpopulations of patients suffering of chronic pain and their response to different treatments. In addition, the correlation between these complex psychophysical, electrophysiological and biological measurements with questionnaires and clinical evaluations will open the way for the development of simple clinical assessment procedures to better guide the treatment of specific subgroups of patients. Ultimately, Doctor Marchand wants to be able to determine the subset of patients who will be more likely to respond to a specific treatment.
- Pythagore Award in Health sciences, UQTR (October 2012)
- UQAT and University of Sherbrooke Joint chair in Pain (2002-2010)
- Recognition Award for a past member of the board of directors, Fondation du CHUS (July 2008)
- Édouard-Montpetit Medal received from the Édouard-Montpetit foundation President, M. Jean-Guy Legault, for implication in Pain Research and Teaching in Québec and Canada. (November 2004)
- Canadians For Health Research, Researcher of the Month (October 2005)
- More than 90 publications in high quality scientific journals including Pain, New England Journal of Medicine, European Journal of Pain, Journal of psychopharmacology
- More than 100 invitations to give conferences at international meetings
Know-How & Opportunities for Collaboration
- Endogenous pain modulation mecanisms measurement : psychophysics
- Electrophysiological responses : spinal (nociceptive reflex), cortical (somatosenory evoqued potentials), autonomic (Heart Rate Variability, Blood Pressure, Galvanic Responses)
- Serum levels of sex hormones and neurotransmitters and their receptors phenotypes
- Analgesic responses to pharmacological and nonpharmalogical treatments