Jean-Paul Praud, M. D.

Jean-Paul PraudInvestigator and Director
Mother & Child Axis
Centre de recherche du CHUS

Canada Research Chair in Neonatal Respiratory Physiology

Pediatric Pulmonologist
Centre hospitalier universitaire de Sherbrooke

Full Professor
Department of Pediatrics | Division of Pneumology
Faculty of Medicine and Health Sciences
Université de Sherbrooke

Contact Information
Phone | 819 346-1110 ext. 14851
E-Mail| Jean-Paul.Praud@USherbrooke.ca

  

Research relevance

Neonatal Respiration

The investigator Jean-Paul Praud’s research has enabled to a new comprehension of neonatal respiration. He has shown that closing of the larynx during repeated apneas of premature newborns is actually beneficial as it creates an oxygen reserve in the lungs. However, the reflexes triggered by acid liquid reflux from the stomach onto the larynx provoke particularly severe apneas and heart rate decreases in premies. A further feature of his research is the unique experimental animal model he pioneered and developed: a preterm-lamb model that remarkably reproduces human apneas of prematurity.

Moreover, Dr Praud designed an innovative telemetry system for studying non-sedated, freely moving lambs, and recording their respiration, blood oxygenation and sleep states. Alongside Doctor Philippe Micheau, from the Department of Mechanical Engineering at Université de Sherbrooke, Dr Jean-Paul Praud has also developed a novel technology to study the impact of secondary cigarette smoke in the neonatal-lamb model.

The main goal of Dr Praud’s research team is to better understand neonatal control of respiration and cardiac activity in order to improve treatment of apneas of prematurity and to prevent sudden infant death syndrome.

Dr Praud is a pediatrician specialized in respiratory medicine. He is director of the Mother & Child Health Axis of the Centre de recherche du Centre hospitalier universitaire de Sherbrooke and Head to the Respiratory Medicine Division, Department of Pediatrics. Dr Praud’ research interests are directly in line with his extensive clinical expertise in neonatal upper airway function, as well as his clinical activities which involve the daily care of infants affected with apneas of prematurity, apparently life-threatening events and the follow-up of families of sudden-infant-death-syndrome victims.

 

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Representative Achievements

  • Excellence Award, Foundation of Stars, formerly known as the Foundation for Research into Children’s Diseases, 1999
  • President, International Congress on Pediatric Pulmonology, Lisbonne, 2002
  • FRQ-S National Researcher,  2003-2008

          

     

Know-How & Opportunities for Collaboration

  • Surgical chronic instrumentation of the lambs, including by thoracic videosurgery
  • Unique neonatal ovine models: preterm lamb, lamb with reflux laryngitis, lamb with isolated upper airways, lamb with nasal ventilation
  • Polysomnographic recordings via radiotelemetry
  • Assessment of neonatal respiratory control, including of the upper airways

       

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