Hervé Walti, M. D., M. Sc.

Hervé WaltiInvestigator
Mother & Child Axis
Centre de recherche du CHUS

Centre hospitalier universitaire de Sherbrooke

Full Professor
Department of pediatrics | Division of Neonatology
Faculty of Medicine and Health Sciences
Université de Sherbrooke

Contact Information
Phone | 819 346-1110 ext. 74633

E-Mail | Herve.Walti@USherbrooke.ca


Research Relevance

Clinical applications of total liquid ventilation

Dr. Walti research focuses on the development of an innovative technique of respiratory support for newborns that have conventional mechanical ventilation refractory respiratory distress. In this technique, the total liquid ventilation (VLT), perfluorocarbon, a breathable liquid is used for gas exchanges. It requires the development of a dedicated liquid ventilator.

Dr. Walti has spent the last decade to design and test this dedicated liquid ventilator in a bi-faculty laboratory which he co-directs with Dr. Philippe Micheau of the Department of mechanical engineering at the Université de Sherbrooke. He led the animal experiments intended to prove the merits and the risk-benefit ratio of this type of ventilation in neonatal respiratory distress ovine experimental models as acute respiratory distress syndrome or meconium aspiration syndrome.

The latest prototype of this liquid ventilator, Inolivent 6.0, integrates the latest technological laboratory advances. This version is considered as the most advanced liquid ventilator in the world.

Current work focuses on weaning and mid-term pulmonary and neurological issues from this technique of ventilation. Furthermore, in collaboration with a French research team (INSERM-U955/3) the laboratory developed the technique of total liquid ventilation as a vector of an ultra-fast cooling method for therapeutic hypothermia.

The main objective of the Inolivent team is the technology transfer of the VLT technique in clinic to support distress respiratory neonatal refractory to the techniques of conventional mechanical ventilation techniques and ineligible to extracorporeal oxygenation techniques.

Dr. Hervé Walti is a Pediatrician specializing in neonatology. He is also Director and head of the Department of Pediatrics and member of the mother and child division from the Centre de recherche du Centre hospitalier universitaire de Sherbrooke and of the Centre de recherche mère-enfant de l’Université de Sherbrooke. Dr. Walti research interests are directly related to his clinical expertise in the field of neonatal intensive care particularly in the most severe neonatal respiratory distress.


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Representative Achievements

  • Grants obtained from Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council of Canada (NSERC), the « Ministère du développement économique de l’innovation et de l’exportation du Québec  (MDEIE) »,Star Foundation
  • Patents on the liquid ventilator Inolivent
  • President of the 6th International Symposium on Perfluorocarbon Application and Liquid Ventilation, 2007, Montreal, Canada


Know-How & Opportunities for Collaboration

  • Neonatal mechanical ventilation
  • Pulmonary surfactant
  • Total liquid ventilation
  • Experimental ovine models of neonatal respiratory distress



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