Lucie Blais, Ph. D.
Pharmacoepidemiology of asthma
Asthma is a frequent disease with more than 8% of Canadians affected. A large proportion of patients have uncontrolled asthma and/or are sub-optimally using their medications. It is therefore essential to describe the use of asthma medications at the population level and to evaluate the impact of sub-optimal use of medications on patients’ health. Asthma is also the most frequent chronic disease during pregnancy. Almost no data on efficacy and effectiveness of asthma medications can be derived from randomized clinical trials since pregnant women are routinely excluded from these studies. In this field of research, pharmacoepidemiology becomes essential to quantify the risks and benefits associated with asthma medications taken during pregnancy, allowing health care professionals and women to take the right decisions concerning asthma therapy. The investigator’s research program, funded mainly by CIHR and FRQ-S, is formed of three main axes:
- Effectiveness and safety of asthma medications during pregnancy
- Use of asthma medications and its impact on patient’s health and use of health care services
- Development of research tools and computerized databases
- Cossette B*, Forget A, Beauchesne M-F, Rey É, Lemière C, Larivée P, Battista M-C, Blais L. Impact of Maternal Use of Asthma-Controller Therapy on Perinatal Outcomes. Thorax.2013 Apr 13.doi: 10.1136/thoraxjnl-2012-203122. [Epub ahead of print]
- Blais L, Kettani FZ, Forget A. Relationship between Maternal Asthma, Its Severity and Control, and Abortions. Hum Reprod. 2013 Apr;28(4):908-15. doi: 10.1093/humrep/det024. Epub 2013 Feb 20.
- Blais L, Kettani F-Z, Beauchesne M-F, Lemière C, Perreault S, Forget A. New Measure of Patients’ Adherence Adjusted for Prescription Patterns: The Case of Adult Asthmatic Patients. Annals of Pharmacotherapy 2011 Mar;45(3):335-41. Epub 2011 Mar 8.
- Breton M-C*, Beauchesne M-F, Lemière C, Rey É, Forget A, Blais L. Risk of Perinatal Mortality Associated with Inhaled Corticosteroids Use for the Treatment of Asthma during Pregnancy. J Allergy Clin Immunol. 2010 Oct;126(4):772-777.e2.
- Blais L, Beauchesne MF, Lemière C, Elftouh N. High Doses of Inhaled Corticosteroids during the First Trimester of Pregnancy and Congenital Malformations. J Allergy ClinImmunol. 2009 Dec;124(6):1229-1234.e34. Epub
Know-How & Opportunities for Collaboration
- Perinatal epidemiology
- Database studies
- Development of computerized databases with clinical and administrative data
- Measurement of compliance