Sherbrooke Molecular Imaging Center

CIMS

Contact our TeamThe Sherbrooke Molecular Imaging Center (Centre d’imagerie moléculaire de Sherbrooke : CIMS) of the Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS) provides a unique range of pre-clinical and clinical imaging modalities to research scientists and industry partners.

The CIMS of CRCHUS has a recognized expertise in Positron Emission Tomography (PET), Magnetic Resonance Imaging (MRI), Computed Tomography (CT) and optical imaging.
  

From bench to bedside

With its two cyclotrons and a complete radiochemistry department, the CIMS of CRCHUS :
  • provide a wide variety of radiotracers and radiopharmaceutical products and conducts the required in vitro and in vivo validation of these agents

  • owns the infrastructure necessary to the development of pre-clinical and clinical applications for the benefit of patients.
  • is specialized in the design, the development and the operation of state-of-the-art pre-clinical scanners and biomedical instrumentation.

   

Services

PRODUCTION AND SALE

We produce medical radioisotopes with short half-life (carbon-11, nitrogen-13, oxygen-15) available on site as well as several other radioisotopes and radiotracers for pre-clinical and clinical research and sale.

We are specialized in radiotracer development for a wide variety of pre-clinical and clinical applications.

Our expertise in the labeling of small molecules, oligonucleotides, peptides, antibodies and proteins facilitates the translation of new radiotracers to clinical practice.
  

Services 
    • Production and sale of medical radioisotopes: Fluoride-18 (18F) , Copper-64 (64Cu) ,  Technetium-99m (99mTc),  Ziconium-89 (89Zr)
    • Radiolabeling of biomolecules and multimodal probes with: 11C, 18F, 64Cu, 89Zr, 124/125I.
    • In vitro and in vivo stability studies
    • Identification of metabolites

 

Infrastructure

The radiochemistry laboratory houses state-of-the-art equipment, and holds an establishment license for production of radiopharmaceuticals according to certified manufacturing practices (GMP).
  

  • Two (2) cyclotrons: TR-19 and TR-24
  • Hot cells
  • Radiosynthesis units
  • Three (3) clean rooms
  • Analytical equipment: HPLC, UPLV, Instant ImagerTM, MS

  

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PRE-CLINICAL

The CIMS of CRCHUS offers a wide range of pre-clinical imaging modalities, including state-of-the-art PET, PET/CT/SPECT, MRI and optical (fluorescence/bioluminescence) scanners, specifically designed for research in pre-clinical models.

We assist and support research scientists and industry partners in designing and conducting their pre-clinical research projects.

Our expertise, based on years of experience in pre-clinical imaging, permits the investigation of normal physiology as well as pathological conditions and the evaluation of new therapies.

Equipped with a facility dedicated to imaging activities, the CIMS of CRCHUS houses a surgery ward.

  

Services
LabPET8
  • Wide range of pre-clinical models
  • Experimental design of pre-clinical studies
  • Imaging packages: cardiology and oncology
  • Surgery and interventional angiography
  • Biodistributions
  • Pre-clinical pharmacokinetic modeling
  • Dosimetry assessment
  • On-site housing on ventilated racks and controlled environment – software-based pre-clinical record management and tracking system

 

Infrastructure
  • Pre-clinical PET/CT/SPECT scanner Triumph™ by TriFoil Imaging
  • QOSPre-clinical PET scanner LabPET™ 4 by TriFoil Imaging
  • Pre-clinical 7 T MRI scanner by Varian
  • Pre-clinical optical QOS™ scanner
  • Cellvizio® Lab DualBand optical micro-endoscope by Mauna Kea Technologies
  • Clinical PET/CT scanner Gemini GXL by Philips
  • Clinical PET/CT scanner Gemini TF by Philips
  • Clinical 3.0T MRI scanner Ingenia by Philips
  • Clinical SPECT scanner OPTIMA™ by GE Healthcare
  • Software-based preclinical record management and tracking system SAITA 3
  • Fully-equipped pre-clinical suites (7) for preparation and injection adjacent to each scanner: medical gases, isoflurane, capture arms, surgery lamps
  • Fully-equipped pre-clinical suites for preparation and injection of Level II and immunosuppressed models
  • Fully-equipped surgery ward and necropsy room: fluoroscopy scanner Mobile C-Arm by Philips
    Biological analysis laboratory: automated gamma counters (Hidex and Cobra II) and Instant Imager™ by Packard

  

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CLINICAL STUDIES

The CIMS of CRCHUS serves a vast population and is actively involved in clinical research: oncology, neurology, cardiology and metabolic diseases.

We assist and support research scientists and our industry partners in designing and conducting their clinical research projects.

 

Services
  • Clinical studies: Phase I, Phase II, Phase III
  • Experimental design of clinical studies and ethical framework
  • Radiotracers assessment
  • Detection, extension assessment, staging and therapeutic follow-ups of cancer
  • Metabolic studies: diabetes and ageing
  • Clinical pharmacokinetic modeling
  • Dosimetry assessment

 

Infrastructure
  • Clinical PET/CT scanner Gemini GXL by Philips
  • Clinical PET/CT scanner Gemini TF by Philips
  • Clinical 3.0T MRI scanner Ingenia by Philips & High density EEG
  • Clinical 1.5T MRI scanner MAGNETOM Sonata by Siemens
  • Biological analysis laboratory: automated gamma counters (Hidex and Cobra II) and Instant Imager™ by Packard

     

   Request a Quote by email

      

DEVELOPMENT OF PRE_CLINICAL SCANNERS

The CIMS of CRCHUS is involved in the design and the development of PET, PET/CT and diffuse optical tomography (DOT), high resolution pre-clinical scanners. Capitalizing on state-of-the-art breakthroughs in photodetection and electronics, the most recent LabPET™ scanners developped at CIMS of CRCHUS offer an excellent submillimetrics spatial resolution. The LabPET™ technology is entirely modular, adaptable to the needs of pre-clinical research and dedicated clinical applications in human.

The expertise in biomedical instrumentation developed at the CIMS of CRCHUS is renown worldwide.

   

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Substances nucléaires utilisées au CIUSSS de l’Estrie - CHUS

Le Service de médecine nucléaire du CIUSSS de l’Estrie – CHUS et CIMS utilisent des substances nucléaires pour les activités cliniques et les activités de recherche. Ces substances sont utilisées notamment pour le diagnostic et le traitement de maladies chez l’humain et les études précliniques sur les animaux. L’usage et la production de ces substances sont contrôlés par la Commission canadienne de sûreté nucléaire (CCSN) qui encadre ces activités réglementées par l’émission de permis. 

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CIMS by image

  • Salle blanche


CIMS Team

Roger LecomteScience Chief CIMS
Roger Lecomte
819-346-1110 #14608

 

 

  

Platforms Manager CIMS
Francis Malenfant
819-346-1110 #12873

Jacques RousseauPre-clinical Operation Manager CIMS
Jacques Rousseau
819-346-1110 #11861

 

   

Eric LavalléeClinical Operation Manager CIMS
Éric Lavallée
819-346-1110 #12887

Catherine PépinScience coordinator CIMS
Catherine Pepin
819-346-11110  #11882

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