Conférence CDRV | The importance of site-specific ROS signalling in ageing


Alberto Sanz, Ph. D

Chercheur principal associé

Newcastle University, United Kingdom

Catégorie | Conférence CDRV

Conférencier | Alberto Sanz, Ph. D

Date | 5 septembre 2017 de 12 h à 13 h

Lieu | Auditorium de l'Hôpital et Centre d'hébergement D'Youville, local 2458

À propos du conférencier

Alberto Sanz obtained a PhD in Biology from the Complutense University of Madrid in 2006. During his PhD studies at laboratory of Prof Gustavo Barja, he studied how mitochondrial ROS levels are altered in response to changes in the diet (Sanz A and col. FASEB J. 2006). He did his postdoc, supported by an EMBO Long Term Fellowship, in the laboratory of Prof Howy Jacobs in Finland, where he generated Drosophila models to manipulate mitochondrial ROS levels in vivo (Fernandez-Ayala and col. 2009. Cell Metabolism & Sanz and col. PNAS. 2010). In 2011, he started his own laboratory, supported by an ERC Starting Grant, to study the role of mitochondria in ageing. Since 2014, his laboratory is based in Newcastle (UK) where he is a Research Fellow of Newcastle University supported by BBSRC, MRC and Wellcome Trust. He is studying how mitochondrial ROS participate in ageing and age-related diseases. Recently, his laboratory has described how site specific ROS signalling can protect mitochondrial function and extend lifespan (Scialo and col. Cell Metabolism. 2016).

Résumé de la conférence

Présentation en anglais

Reactive Oxygen Species (ROS) are thought to be a primary factor in ageing and age-related diseases. However, ROS participate, as cellular messengers, in essential physiological processes including cell differentiation, the immune response and cancer progression. The participation of ROS in physiological processes is associated with specific ROS signals generated at or by specific respiratory complexes in response to precise stimuli. Conversely, in ageing and age-associated pathologies it is associated with the production of a general unspecific ROS.  

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