Conférence CRCHUS | Gold nanoparticles as a platform for targeted local radiation treatment of breast cancer

2017-05-09

Raymond M. Reilly, Ph.D.

Professor and Director, Centre for Pharmaceutical Oncology

Leslie Dan Faculty of Pharmacy, University of Toronto

Catégorie | Conférence CRCHUS

Conférencier | Raymond M. Reilly, Ph.D.

Axes | Cancer: biologie, pronostic et diagnostic et Imagerie médicale

Date | Mardi 9 mai 2017 à 12 h

Lieu | local 2999

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Résumé

Gold nanoparticles (AuNP) present a versatile platform for the synthesis of targeted radiation treatments for cancer since they may be surface-modified with antibodies to target tumour-associated receptors as well as with polymers that present chelators for radiometal labeling. In this presentation, I will discuss strategies to modify AuNP with panitumumab or trastuzumab for targeting epidermal growth factor receptors (EGFR) or HER2 respectively, overexpressed in breast cancer. I will discuss modification of the gold surface with polyethylene glycol (PEG) polymers linked to DTPA or DOTA chelators that complex the Auger electron-emitter, 111In or the b-particle emitter, 177Lu. Studies evaluating the ability of these radiolabeled AuNP to kill breast cancer cells in vitro in clonogenic assays, as well as their ability to arrest tumour growth in mice with minimal normal tissue toxicity following intratumoural injection with be described. A novel implantable depot system has been developed to enable local administration of these radiolabeled AuNP. The tumour dosimetry using this system will be presented. Research was supported by a grant from the Canadian Breast Cancer Foundation.

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