Conférence CRCHUS | Resonance Imaging of Brown Adipose Tissue
E. Brian Welch, Ph.D., M.B.A.
Department of Radiology and Radiological Sciences
Department of Biomedical Engineering
Vanderbilt University Institute of Imaging Science (VUIIS)
Vanderbilt University Medical Center, Nashville, TN
Catégorie | Conférence CRCHUS
Conférencier | E. Brian Welch, Ph.D., M.B.A.
Date | Mardi 12 septembre 2017 à 12 h
Lieu | local 2999
Conférence en anglais seulement
Brown adipose tissue (BAT) is a thermogenic tissue known to be present in many small mammals and human infants. In human subjects, BAT is believed to diminish with age and be essentially undetectable in adults. However, recent 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) studies show that small but metabolically significant amounts of BAT persist into adulthood. These studies further suggest an inverse relationship between BAT and obesity, although it remains unclear whether reduced BAT amount and/or activity promotes or results from obesity. The most commonly employed imaging method for differentiating BAT and white adipose tissue (WAT) uses a combination of 18F-FDG PET and x-ray computed tomography (CT), which requires an undesirable radiation dose. An alternative to PET-CT is magnetic resonance imaging (MRI). MRI does not use ionizing radiation and is well suited for longitudinal studies and investigations of radiation-sensitive subjects such as children. Multiple MRI methods can detect and characterize human BAT. Example MRI methods for BAT detection include quantitative fat-signal fraction mapping, fat-water separated thermometry, T2 mapping, dynamic T2*-weighted imaging, hyperpolarized xenon imaging, dynamic contrast enhanced imaging, and perfusion/diffusion imaging. This talk presents an overview of the various MRI methods for imaging BAT with a special focus on quantitative fat-fraction mapping.